MPICH2 relies heavily on Python to build it's TotalView support module, mtv.so. It needs the python Makefile found in /usr/lib/python2.X/config/ It should be compatible with versions 2.3 and above, perhaps with 2.2. Any change in python on the system may require a rebuild or retention of the older python libraries, as unresolved symbols may prevent TotalView from working or acquiring the full set of processes in the MPI job.